Design

Why these projects?
Projects Overview

Why these projects?

Projects Overview

Hardware

Component	Priority	Objective	Assigned to	Report to
Microfluidic Pump	1	TBD		Piyush
Microfluidic Chip (DNA Synthesis)	2	Create a chip with exposed -OH groups with highly turbulent flow over the mixing region to achieve Solid Phase DNA Synthesis.	Matthias, Patt	Tina, Piyush
Microfluidic Chip (PCR)	2	Create a connected PCR chip which can amplify free floating single stranded DNA.	Samuel, Piyush	Tina, Piyush
Microfluidic Chip (DNA Capture)	2	TBD	Samuel, Piyush	Tina, Piyush
Bioreactor	2	Create a Bioreactor to allow Wet Lab to Culture E Coli for their experiments	Samuel, Piyush	Tina, Piyush

Software

Component	Priority	Objective	Assigned to	Report to
Encoding	2	Implement a software pipeline that when given a file location to write to DNA, creates the DNA sequence(s) to be synthesized	Sebastian, Lucy	Lucy
Decoding	2	Implement a software pipeline that when given a request to retrieve a file, does the opposite of encoding	Riya, Lucy	Lucy
In silico testing	1	Given an input string, error rate of DNA synthesis generate faulty sequences to test against our encoding/decoding algorithm	Lucy, Sebastian, Riya	Lucy
Error Correction	1	Create an error correction algorithm to work with semi-specific encoding, short nucleotide sequences and high rate of deletion errors.	Riya, Lucy	Lucy
GUI	3	Design a user friendly interface that can be used by our iHP interviewees to try out our DNA storage software	All software + other dry lab if desired	Lucy

Modelling

Component	Priority	Objective	Assigned to	Report to
TdT Reaction Kinetics	3	Design an expression for the reaction kinetics of TdT. The result would be an expression where we could find the concentration of cofactors, reagents, etc that allow the kinetics of nucleotide addition to be equal for all nucleotides (A, T, G, C)	Lucy, Piyush	Wet Lab Leads
Bioreactor Modelling	3	TBD